Candida spp. AST - MIC breakpoint 변천사

Candida spp. AST – MIC breakpoint 변화 과정 (2008 → 2012 → 2022)

CLSI M27 A2_2008 - Voriconazole을 포함한 new triazole의 MIC breakpoint 설정하기 전.

M27 A = Yeast AST, Approved Standard

M27 S = Yeast AST, Informational Supplement

 

CLSI M27 A3/S3_2008 - Candida spp.에 대한 Voriconazole MIC breakpoint 설정.

 

CLSI M27 A4/S4_2012 - Candida spp.의 각 종별로 Antifungal agent들의 MIC breakpoint 제시

 

CLSI M27M44S ED3_2022 (가장 최신 버전)

 

Fluconazole R, Voriconazole S Isolate의 Epidemiology? 

- Case-Case-Control Study on Non-albicans Candida (NAC) isolates, 총 259건

- Mono-resistant (MR) NAC isolate: 33건 – Fluconazole R (30건) + Voriconazole R (3건)

  Cross-resistant (CR) NAC isolate: 27건

  Non-resistant (NR) NAC isolate: 199건

- Ref) Eur J Clin Microbiol Infect Dis. 2017;36(11):2117-2126.